达那唑对月经过多、凝血机制、血液学指标及体重的影响。

The effect of danazol on menorrhagia, coagulation mechanisms, haematological indices and body weight.

作者信息

Chimbira T H, Cope E, Anderson A B, Bolton F G

出版信息

Br J Obstet Gynaecol. 1979 Jan;86(1):46-50. doi: 10.1111/j.1471-0528.1979.tb10683.x.

DOI:10.1111/j.1471-0528.1979.tb10683.x

Abstract

Eighteen patients with objective evidence of menorrhagia (more than 80 ml menstrual blood loss) were treated with danazol for twelve weeks. Danazol significantly reduced the menstrual blood loss from 231 +/- 39 ml (mean +/- SEM) to 135 +/- 33 ml in the first treatment month and the mean loss thereafter was only 21 ml and 3 ml for the second and third months respectively. A rapid increase in haemoglobin level and a reduction in the number of days of bleeding were also observed on danazol treatment. No important effect on the coagulation profile was observed during the period of study. Three months after stopping danazol, menstrual blood loss (103 +/- 27 ml) was still significantly less than the pre-treatment loss.

摘要

18例有明显月经过多证据（月经失血量超过80毫升）的患者接受了达那唑治疗，为期12周。在第一个治疗月，达那唑使月经失血量从231±39毫升（均值±标准误）显著减少至135±33毫升，此后第二个月和第三个月的平均失血量分别仅为21毫升和3毫升。在接受达那唑治疗期间，还观察到血红蛋白水平迅速升高以及出血天数减少。在研究期间，未观察到达那唑对凝血指标有重要影响。停用达那唑三个月后，月经失血量（103±27毫升）仍显著低于治疗前的失血量。