人类胶原酶-3（CLG3）基因位于11号染色体的11q22.3区域，与基质金属蛋白酶基因家族的其他成员聚集在一起。
The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family.
作者信息
Pendás A M, Matilla T, Estivill X, López-Otín C
机构信息
Departamento de Biología Funcional, Universidad de Oviedo, Spain.
出版信息
Genomics. 1995 Apr 10;26(3):615-8. doi: 10.1016/0888-7543(95)80186-p.
The gene coding for human collagenase-3 (CLG3), a recently described matrix metalloproteinase produced by breast carcinomas, has been localized by fluorescence in situ hybridization on chromosome 11q22.3. Physical mapping of an isolated YAC clone containing CLG3 has revealed that this gene is tightly linked to those encoding other matrix metalloproteinases, including fibroblast collagenase (CLG1), stromelysin-1 (STMY1), and stromelysin-2 (STMY2). Further mapping of this region using pulsed-field gel electrophoresis has shown that the CLG3 gene is localized to the telomeric side of the matrix metalloproteinase cluster, the relative order of the loci being centromere-STMY2-CLG1-STMY1-CLG3-telomere.
人胶原酶-3（CLG3）是一种最近发现的由乳腺癌产生的基质金属蛋白酶，其编码基因已通过荧光原位杂交定位到11号染色体的q22.3区域。对一个含有CLG3的分离YAC克隆进行物理图谱分析表明，该基因与编码其他基质金属蛋白酶的基因紧密相连，这些基质金属蛋白酶包括成纤维细胞胶原酶（CLG1）、基质溶解素-1（STMY1）和基质溶解素-2（STMY2）。使用脉冲场凝胶电泳对该区域进行进一步图谱分析表明，CLG3基因定位于基质金属蛋白酶簇的端粒侧，基因座的相对顺序为着丝粒-STMY2-CLG1-STMY1-CLG3-端粒。
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