Warner V, Mufson L, Weissman M M
New York State Psychiatric Institute, NY 10032, USA.
J Am Acad Child Adolesc Psychiatry. 1995 Jun;34(6):786-97. doi: 10.1097/00004583-199506000-00020.
To examine the effect of parental psychiatric diagnosis on the risk of psychiatric disorder in their offspring and to determine mediators and independent predictors of psychiatric disorder in offspring.
The sample consisted of 145 offspring (between the ages of 6 and 24 years, who were directly interviewed) of probands with early-onset (before age 30 years) major depressive disorder (MDD) without panic, panic disorder with and without major depression, and a normal, never psychiatrically ill control group who were part of a large study conducted to determine the relationship between panic disorder and major depression.
The risk for offspring MDD was increased by proband recurrent early-onset MDD and coparent alcohol abuse. Chaotic family environment was the only independent predictor of dysthymia. The risk for offspring "any anxiety" disorder was increased by proband recurrent early-onset MDD and coparent impaired functioning. The association between MDD in proband and "panic spectrum" disorder in offspring was accounted for by chaotic family environment.
Recurrent parental MDD has consistently been shown to be a strong risk factor for offspring MDD. Family environment plays an important role in low-level anxiety symptoms and dysthymia. Clinicians treating adults should be alert to risk factors for their offspring and to appropriate targets for early intervention.
研究父母的精神疾病诊断对其子女患精神障碍风险的影响，并确定子女精神障碍的中介因素和独立预测因素。
样本包括145名先证者的子女（年龄在6至24岁之间，接受直接访谈），这些先证者患有早发性（30岁之前）无惊恐症状的重度抑郁症（MDD）、伴有或不伴有重度抑郁症的惊恐障碍，以及一个正常的、从未患过精神疾病的对照组，他们是一项旨在确定惊恐障碍与重度抑郁症之间关系的大型研究的一部分。
先证者复发性早发性MDD和共同父母酗酒会增加子女患MDD的风险。混乱的家庭环境是心境恶劣障碍的唯一独立预测因素。先证者复发性早发性MDD和共同父母功能受损会增加子女患“任何焦虑”障碍的风险。先证者的MDD与子女的“惊恐谱系”障碍之间的关联可由混乱的家庭环境来解释。
父母复发性MDD一直被证明是子女患MDD的一个强大风险因素。家庭环境在低水平焦虑症状和心境恶劣障碍中起重要作用。治疗成人的临床医生应警惕其子女的风险因素以及早期干预的合适目标。
