Nishiuchi S, Okazaki T, Shinkai M, Fujiwara H, Nasu M, Sono J, Okada Y, Miyamoto S, Shomura T
Department of Thoracic and Cardiovascular Surgery, Kobe City General Hospital, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1995 Apr;43(4):473-8.
The objective of this study is to evaluate safety and efficacy of the selective cerebral perfusion (SCP) for an adjunct to perform operation of aortic arch aneurysms. From November 1982 to June 1993, surgical treatment of aneurysm of aortic arch using SCP was performed in 22 patients. The hospital death was accounted in 5 cases (23%), the intraoperative stroke was observed in 3 cases (14%) and these patients died. The cause of intraoperative stroke was cerebral hypoperfusion due to multiple sclerosis of intracranial arteries or insufficient SCP. Variables of an increased operative risk seemed to be older age (over 70 y.o.) and rupture. SCP time more than 120 minutes did not promote the operative risk. Cerebral hypoperfusion was directly responsible for not only intraoperative stroke, but also operative death. Therefore, SCP seems effective and safe if hypoperfusion is prevented.
本研究的目的是评估选择性脑灌注(SCP)作为主动脉弓动脉瘤手术辅助手段的安全性和有效性。1982年11月至1993年6月,对22例患者采用SCP进行主动脉弓动脉瘤手术治疗。5例(23%)出现医院死亡,3例(14%)观察到术中卒中,这些患者死亡。术中卒中的原因是颅内动脉多发性硬化或SCP不足导致的脑灌注不足。手术风险增加的因素似乎是高龄(70岁以上)和动脉瘤破裂。SCP时间超过120分钟并未增加手术风险。脑灌注不足不仅是术中卒中和手术死亡的直接原因。因此,如果能预防灌注不足,SCP似乎是有效且安全的。