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胸主动脉瘤手术期间脑保护的比较研究

Comparative study of cerebral protection during surgery of thoracic aortic aneurysm.

作者信息

Sueda T, Nomimura T, Kagawa T, Morita S, Hayashi S, Orihashi K, Shikata H, Ryuu G, Hamanaka Y, Matsuura Y

机构信息

First Department of Surgery, Hiroshima University School of Medicine, Japan.

出版信息

Hiroshima J Med Sci. 1992 Jun;41(2):31-5.

PMID:1286973
Abstract

During the past 5 years, 30 cases of thoracic aortic aneurysm were treated. Selective cerebral perfusion (SCP) and retrograde cerebral perfusion (RCP) were conducted for cerebral protection during aortic cross clamping. SCP was carried out in 5 cases of dissecting aneurysm (all Stanford type A, including a case of AAE) and 3 cases of arch aneurysm. RCP was conducted in 5 cases of dissecting aneurysm (4 Stanford type A, 1 Stanford type B with retrograde dissection) and 2 cases of aortic arch aneurysm. The mean cerebral perfusion time of SCP exceeded that of RCP (89 +/- 26 min in SCP versus 61 +/- 33 min in RCP p < 0.05). The hospital mortality rate was 38% (SCP) and 29% (RCP). Neurological complications were prolonged unconsciousness (1/8 in SCP, 1/7 in RCP) and transient paralysis (0/8 in SCP, 1/7 in RCP). Although the mechanism for the cerebral protective effect of RCP is unknown, this perfusion method is easy and safe, requiring little time for ascending and/or arch aortic reconstruction.

摘要

在过去5年中,共治疗了30例胸主动脉瘤。在主动脉阻断期间,采用选择性脑灌注(SCP)和逆行脑灌注(RCP)进行脑保护。5例夹层动脉瘤(均为斯坦福A型,包括1例主动脉弓夹层动脉瘤)和3例弓部动脉瘤采用了SCP。5例夹层动脉瘤(4例斯坦福A型,1例伴有逆行夹层的斯坦福B型)和2例主动脉弓动脉瘤采用了RCP。SCP的平均脑灌注时间超过RCP(SCP为89±26分钟,RCP为61±33分钟,p<0.05)。医院死亡率分别为38%(SCP)和29%(RCP)。神经并发症包括昏迷时间延长(SCP组8例中有1例,RCP组7例中有1例)和短暂性瘫痪(SCP组8例中无,RCP组7例中有1例)。尽管RCP脑保护作用的机制尚不清楚,但这种灌注方法简便、安全,升主动脉和/或主动脉弓重建所需时间短。

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