Kayano K, Takeo M, Morisue S, Yamamoto M, Mizuno Y, Meguro F
Department of Surgery, Kobe West City Hospital, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1995 Apr;43(4):538-42.
The authors reported a case of a 56-year-old man with lung cancer which secreted human growth hormone (hGH). On admission, he had clubbed fingers and gonalgia without complaining cough or sputum. Serological examination revealed a high level of hGH which was 22.7 ng/ml (normal < 1.46). Right upper lobectomy was performed in February, 1994. It returned to the normal level after resection of the tumor. Gonalgia was improved but he still had clubbed fingers after operation. Histological examination of the tumor shows poorly differentiated adenocarcinoma with no evidence of lymph node metastasis. Immunohistochemical study showed that a group of the tumor cells demonstrated a specific reaction for anti-hGH antibody.
作者报告了一例56岁分泌人生长激素（hGH）的肺癌男性患者。入院时，他有杵状指和膝痛，无咳嗽或咳痰主诉。血清学检查显示hGH水平很高，为22.7 ng/ml（正常<1.46）。1994年2月行右上叶切除术。肿瘤切除后hGH水平恢复正常。膝痛有所改善，但术后仍有杵状指。肿瘤组织学检查显示为低分化腺癌，无淋巴结转移证据。免疫组织化学研究显示一组肿瘤细胞对抗hGH抗体呈特异性反应。
