Lutsep H L, Wessinger C M, Gazzaniga M S
Center for Neuroscience, University of California Davis 95616, USA.
J Neurol Neurosurg Psychiatry. 1995 Jul;59(1):50-4. doi: 10.1136/jnnp.59.1.50.
Patients described in previous reports who have undergone corpus callostomy for control of seizures have been left hemisphere dominant for language. To determine the hemispheric localisation (and possible coexistence) of language and traditional right hemisphere skills in reversed dominance, the first right hemisphere dominant corpus callostomy patient was studied. Localisation of callosal functions was also investigated, as MRI showed 1.5 cm of spared callosal body. The patient, KO, a 15 year old girl with familial left handedness, underwent two stage callosotomy in 1988. Lateralised visually presented stimuli requiring same or different comparisons between visual fields showed chance performance. Oral naming and reading showed better performance by the right hemisphere than the left, whereas both hemispheres were proficient in auditory comprehension. Active voice syntax was above chance only in the right hemisphere. Face recognition was significantly better in the right hemisphere than in the left. Tasks requiring tactile comparisons between hands showed above chance performance except in the instance in which the non-dominant right hand was stimulated first in a point localisation task between hands. This case showed hemispheric coexistence of language and traditional right hemispheric skills in a corpus callosotomy patient with reversed language dominance. Tactile transfer was localised to the mid-posterior callosal body.
在先前报告中描述的因控制癫痫发作而接受胼胝体切开术的患者，其语言功能以左半球为主。为了确定在语言优势反转的情况下语言和传统右半球技能的半球定位（以及可能的共存情况），对首例右半球优势的胼胝体切开术患者进行了研究。由于磁共振成像显示胼胝体有1.5厘米的保留部分，因此也对胼胝体功能的定位进行了研究。患者KO是一名15岁的家族性左利手女孩，于1988年接受了两阶段胼胝体切开术。对视野之间需要相同或不同比较的视觉呈现刺激进行侧化测试，结果显示其表现为随机水平。口头命名和阅读方面，右半球的表现优于左半球，而两个半球在听觉理解方面都很熟练。主动语态句法仅在右半球的表现高于随机水平。右半球的面部识别能力明显优于左半球。除了在双手之间的点定位任务中首先刺激非优势右手的情况外，需要双手进行触觉比较的任务表现均高于随机水平。该病例显示，在一名语言优势反转的胼胝体切开术患者中，语言和传统右半球技能在半球中共存。触觉转移定位于胼胝体中后部。
