Bandmann O, Davis M B, Marsden C D, Harding A E
University Department of Clinical Neurology, (Neurogenetics Section), Institute of Neurology, London, UK.
J Neurol Neurosurg Psychiatry. 1995 Jul;59(1):90-1. doi: 10.1136/jnnp.59.1.90.
Mutations in the superoxide dismutase 1 (SOD1) gene have been detected in affected members of some families with familial amyotrophic lateral sclerosis. To evaluate the possibility of a shared genetic defect in amyotrophic lateral sclerosis and Parkinson's disease, the SOD1 gene was sequenced in index patients with familial Parkinson's disease from 23 families. No changes were detected.
在一些患有家族性肌萎缩侧索硬化症的家族的患病成员中，已检测到超氧化物歧化酶1（SOD1）基因突变。为评估肌萎缩侧索硬化症和帕金森病存在共同遗传缺陷的可能性，对来自23个家族的家族性帕金森病索引患者的SOD1基因进行了测序。未检测到变化。
