Friesen C A, Zwick D L, Streed C J, Zalles C, Roberts C C
Department of Gastroenterology, Children's Mercy Hospital, Kansas City, Missouri 64108, USA.
J Pediatr Gastroenterol Nutr. 1995 Apr;20(3):300-4. doi: 10.1097/00005176-199504000-00006.
Fifty-three infants 0-6 months of age with abnormal 24-h intraesophageal pH monitoring were evaluated by esophageal suction biopsies and endoscopic grasp biopsies. Histologic esophagitis was present in 30% of the infants. Of the infants with esophagitis, 88% were accurately identified by suction biopsy, and 75% were accurately identified by endoscopic grasp biopsy. Suction biopsy alone was not significantly different from combined grasp and suction biopsy, while differences between grasp biopsy and combined biopsy approached significance (p = 0.051). Twelve clinical symptoms and 21 intraesophageal pH monitoring parameters were evaluated for their ability to predict esophagitis, and none were found to be useful. We conclude that endoscopic esophageal biopsy, while more costly, offers no advantage over suction biopsy for the detection of esophagitis in young infants.
对53名年龄在0至6个月、24小时食管内pH监测异常的婴儿进行了食管吸引活检和内镜钳取活检评估。30%的婴儿存在组织学食管炎。在患有食管炎的婴儿中，88%可通过吸引活检准确识别，75%可通过内镜钳取活检准确识别。单纯吸引活检与钳取活检联合吸引活检相比无显著差异，而钳取活检与联合活检之间的差异接近显著水平（p = 0.051）。对12种临床症状和21项食管内pH监测参数预测食管炎的能力进行了评估，未发现有用的指标。我们得出结论，内镜食管活检虽然成本更高，但在检测幼儿食管炎方面并不比吸引活检更具优势。
