前列腺素前体缺乏对妊娠兔血管对血管紧张素II的敏感性及对肾脏的影响。
The effects of deprivation of prostaglandin precursors on vascular sensitivity to angiotensin II and on the kidney in the pregnant rabbit.
作者信息
O'Brien P M, Broughton Pipkin F
出版信息
Br J Pharmacol. 1979 Jan;65(1):29-34. doi: 10.1111/j.1476-5381.1979.tb17330.x.
Abstract
1 Pregnant rabbits were deprived of essential fatty acids from day ten of pregnancy, and results compared with a control group on a normal diet. 2 At term, cannulation of jugular and carotid vessels was performed under anaesthesia, to study the vascular sensitivity to angiotensin II and basal blood pressure. 3 Plasma renin levels, urinary electrolytes and protein were measured. 4 Placental and renal tissue was examined histologically. 5 Though no changes were found in tissues, blood or urine, a markedly significant increase in response to angiotensin II was found in the group deprived of essential fatty acids. This parallels the findings in vascular response in human pre-eclampsia.
摘要
- 怀孕兔子从妊娠第10天起被剥夺必需脂肪酸，并将结果与正常饮食的对照组进行比较。2. 足月时，在麻醉下进行颈静脉和颈动脉插管，以研究血管对血管紧张素II的敏感性和基础血压。3. 测量血浆肾素水平、尿电解质和蛋白质。4. 对胎盘和肾脏组织进行组织学检查。5. 尽管在组织、血液或尿液中未发现变化，但在被剥夺必需脂肪酸的组中发现对血管紧张素II的反应显著增加。这与人类先兆子痫血管反应的研究结果相似。
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