5'-三磷酸腺苷（ATP）和β-γ-亚甲基三磷酸腺苷对大鼠膀胱的影响。
Effects of adenosine 5'-triphosphate (ATP) and beta-gamma-methylene ATP on the rat urinary bladder.
作者信息
Brown C, Burnstock G, Cocks T
出版信息
Br J Pharmacol. 1979 Jan;65(1):97-102. doi: 10.1111/j.1476-5381.1979.tb17337.x.
Abstract
1 High concentrations of adenosine 5'-triphosphate (ATP, 100 to 1000 micrometer) were required to cause contraction of the rat urinary bladder, while adenosine and adenosine 5'monophosphate (AMP, 1 to 50 micrometer) produced relaxation. 2 One hundred fold lower concentrations of beta-gamma-methylene ATP, which is resistant to degradation to AMP and adenosine, caused dose-dependent, phasic contractions which mimicked atropine-resistant responses to nerve stimulation. 3 Adenosine and AMP caused dose-dependent inhibition of carbachol-induced contractions; theophylline competitively antagonized this inhibition but not the contractile responses to beta-gamma-methylene ATP, ATP or atropine-resistant nerve stimulation. 4 These results suggest that the insensitivity of the rat bladder to ATP is due to its rapid degradation to AMP and adenosine and support the hypothesis that the bladder receives a purinergic excitatory innervation.
摘要
- 需要高浓度的腺苷5'-三磷酸（ATP，100至1000微摩尔）才能引起大鼠膀胱收缩，而腺苷和腺苷5'-单磷酸（AMP，1至50微摩尔）则产生舒张作用。2. 对降解为AMP和腺苷具有抗性的β-γ-亚甲基ATP浓度比ATP低100倍，可引起剂量依赖性的阶段性收缩，模拟了对神经刺激的阿托品抗性反应。3. 腺苷和AMP引起对卡巴胆碱诱导收缩的剂量依赖性抑制；茶碱竞争性拮抗这种抑制，但不拮抗对β-γ-亚甲基ATP、ATP或阿托品抗性神经刺激的收缩反应。4. 这些结果表明，大鼠膀胱对ATP不敏感是由于其迅速降解为AMP和腺苷，并支持膀胱接受嘌呤能兴奋性神经支配的假说。
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