腺苷 5'-(β,γ-亚甲基)-二磷酸酯对映体和 P 物质对豚鼠膀胱的脱敏作用。
Desensitization of the guinea-pig urinary bladder by the enantiomers of adenylyl 5'-(beta, gamma-methylene)-diphosphonate and by substance P.
作者信息
Hourani S M
出版信息
Br J Pharmacol. 1984 May;82(1):161-4. doi: 10.1111/j.1476-5381.1984.tb16454.x.
Abstract
Adenosine 5'-triphosphate (ATP), substance P (SP) and non-cholinergic nerve stimulation contracted the guinea-pig urinary bladder. SP and two poorly-degradable analogues of ATP, the enantiomers of adenylyl 5'-(beta, gamma-methylene)-diphosphonate (AMP-PCP and L-AMP-PCP), were used to desensitize the guinea-pig bladder. Desensitization of the bladder by AMP-PCP (50 microM) or by L-AMP-PCP (50 microM) abolished the responses to ATP, and inhibited the responses to non-cholinergic nerve stimulation and to SP. The responses to histamine were unaffected. Desensitization by SP (1 microM) inhibited the responses to SP itself, but not the responses to ATP, L-AMP-PCP or non-cholinergic nerve stimulation. These results suggest that SP may act partly by releasing ATP, and support the suggestion that ATP rather than SP is the non-cholinergic stimulatory transmitter.
摘要
5'-三磷酸腺苷（ATP）、P物质（SP）和非胆碱能神经刺激可使豚鼠膀胱收缩。SP以及两种降解缓慢的ATP类似物，即腺苷5'-（β，γ-亚甲基）-二磷酸酯的对映体（AMP-PCP和L-AMP-PCP），被用于使豚鼠膀胱脱敏。AMP-PCP（50微摩尔）或L-AMP-PCP（50微摩尔）使膀胱脱敏后，消除了对ATP的反应，并抑制了对非胆碱能神经刺激和SP的反应。对组胺的反应未受影响。SP（1微摩尔）使膀胱脱敏后，抑制了对SP自身的反应，但不抑制对ATP、L-AMP-PCP或非胆碱能神经刺激的反应。这些结果表明，SP可能部分通过释放ATP发挥作用，并支持了ATP而非SP是非胆碱能刺激递质的观点。
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Can J Physiol Pharmacol. 1981 Nov;59(11):1199-201. doi: 10.1139/y81-187.
2
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3
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4
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