疫苗介导的对泰勒氏鼠脑脊髓炎病毒诱导的中枢神经系统疾病的保护作用对B淋巴细胞的需求。
B-lymphocyte requirement for vaccine-mediated protection from Theiler's murine encephalomyelitis virus-induced central nervous system disease.
作者信息
Kurtz C I, Sun X M, Fujinami R S
机构信息
Department of Neurology, University of Utah School of Medicine, Salt Lake City 84132, USA.
出版信息
J Virol. 1995 Aug;69(8):5152-5. doi: 10.1128/JVI.69.8.5152-5155.1995.
Abstract
The role of humoral immunity in the protection of vaccinated SJL/J mice from central nervous system disease induced by the DA strain (DAV) of Theiler's murine encephalomyelitis virus was investigated in B-cell-deficient mice. Mice were depleted of B cells by treatment with a mouse monoclonal antibody specific for immunoglobulin M. DAV-vaccinated, B-cell-deficient mice failed to clear viral infection and were no longer protected from Theiler's murine encephalomyelitis virus-mediated central nervous system disease. CD4+ T cells are required in this model of protection to provide help for the development of an antiviral antibody response in the central nervous system.
摘要
在B细胞缺陷小鼠中研究了体液免疫在保护接种疫苗的SJL/J小鼠免受泰勒氏鼠脑脊髓炎病毒DA株（DAV）诱导的中枢神经系统疾病中的作用。通过用针对免疫球蛋白M的小鼠单克隆抗体处理使小鼠的B细胞耗竭。接种DAV的B细胞缺陷小鼠未能清除病毒感染，并且不再受到泰勒氏鼠脑脊髓炎病毒介导的中枢神经系统疾病的保护。在这种保护模型中，需要CD4 + T细胞来为中枢神经系统中抗病毒抗体反应的发展提供帮助。
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