人免疫缺陷病毒1型反式显性负性rev突变体对猿猴免疫缺陷病毒复制的抑制作用
Suppression of simian immunodeficiency virus replication by human immunodeficiency virus type 1 trans-dominant negative rev mutants.
作者信息
Endres C L, Bergquam E P, Axthelm M K, Wong S W
机构信息
Division of Pathobiology and Immunology, Oregon Regional Primate Research Center, Beaverton 97006, USA.
出版信息
J Virol. 1995 Aug;69(8):5164-6. doi: 10.1128/JVI.69.8.5164-5166.1995.
Abstract
We demonstrate that trans-dominant negative rev mutants are able to suppress simian immunodeficiency virus provirus replication in both transient cotransfection assays and stably transduced HUT 78 cells. These studies suggest that the efficacy of trans-dominant rev strategies in reducing viral burden may be evaluated in a simian immunodeficiency virus-rhesus macaque animal model.
摘要
我们证明，反式显性负性rev突变体在瞬时共转染试验和稳定转导的HUT 78细胞中均能抑制猿猴免疫缺陷病毒原病毒的复制。这些研究表明，可在猿猴免疫缺陷病毒-恒河猴动物模型中评估反式显性rev策略在降低病毒载量方面的功效。
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