树脂毒素和辣椒素对清醒状态下有无流出道梗阻大鼠膀胱内灌注后的尿动力学影响。
Urodynamic effects of intravesical resiniferatoxin and capsaicin in conscious rats with and without outflow obstruction.
作者信息
Ishizuka O, Mattiasson A, Andersson K E
机构信息
Department of Urology, Lund University Hospital, Sweden.
出版信息
J Urol. 1995 Aug;154(2 Pt 1):611-6. doi: 10.1097/00005392-199508000-00080.
PURPOSE
The urodynamic effects of intravesical resiniferatoxin and capsaicin were investigated in rats.
MATERIALS AND METHODS
Continuous cystometry was performed in conscious, female Sprague-Dawley rats with and without outflow obstruction.
RESULTS
Intravesical instillation of resiniferatoxin facilitated micturition. The potency of the drug was approximately 1,000 times higher than that of capsaicin. Repeated instillations of resiniferatoxin for 6 consecutive days caused desensitization to resiniferatoxin. This was not found with repeated instillations of capsaicin. Capsaicin was also effective in rats with bladder hypertrophy, while resiniferatoxin was not.
CONCLUSIONS
The findings suggest that resiniferatoxin can induce desensitization of vanilloid receptor-mediated release of tachykinins in the rat urinary bladder and that intravesical resiniferatoxin would be an interesting alternative to intravesical capsaicin in the treatment of selected cases of bladder hypersensitivity/hyperactivity.
目的
研究大鼠膀胱内树脂毒素和辣椒素的尿动力学效应。
材料与方法
对有或无流出道梗阻的清醒雌性Sprague-Dawley大鼠进行连续膀胱测压。
结果
膀胱内灌注树脂毒素促进排尿。该药物的效力比辣椒素高约1000倍。连续6天重复灌注树脂毒素导致对树脂毒素脱敏。重复灌注辣椒素未发现这种情况。辣椒素对膀胱肥大的大鼠也有效，而树脂毒素则无效。
结论
研究结果表明，树脂毒素可诱导大鼠膀胱中香草酸受体介导的速激肽释放脱敏，膀胱内灌注树脂毒素可能是治疗某些膀胱过敏/活动亢进病例的一种有趣替代方法，可替代膀胱内灌注辣椒素。
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