Asao Y, Matsumoto M, Wake M, Aono H, Kitamura Y, Kayano K, Meguro F
Department of Anesthesia, Kobe West Municipal Hospital.
Masui. 1995 May;44(5):729-31.
Insulinoma is one of the causes of hypoglycemia and can be cured by surgery. Using the enzyme immunoassay kit (ERUMOTEC INSULIN, Mochida Pharmacy Co.), immunoreactive insulin (IRI) can be measured within one hour. Curative operation was confirmed by normalized IRI level. A 58-year-old man had an episode of loss of consciousness. His blood glucose was below, and his IRI was above, normal. These and other examinations revealed that he was suffering from insulinoma. Tumor resection under general anesthesia was scheduled. Glucose was continuously administered intravenously to prevent hypoglycemia until the end of tumor resection. Frequent blood glucose measurement showed that he had no hypoglycemic episodes. Using the enzyme immunoassay kit, IRI was found to be 704 microU.ml-1 during manipulation of the tumor. At 30 minutes after the tumor resection, it decreased to 9.8 microU.ml-1 (within normal ranges). These data suggested that the operation was curative and that no further hypoglycemic attacks by remnant insulinomas would be anticipated.
胰岛素瘤是低血糖的病因之一，可通过手术治愈。使用酶免疫分析试剂盒（ERUMOTEC INSULIN，日本持田制药株式会社），可在一小时内测定免疫反应性胰岛素（IRI）。通过IRI水平恢复正常证实手术治愈。一名58岁男性曾有一次意识丧失发作。他的血糖低于正常水平，而IRI高于正常水平。这些及其他检查显示他患有胰岛素瘤。计划在全身麻醉下进行肿瘤切除。在肿瘤切除结束前持续静脉输注葡萄糖以预防低血糖。频繁测量血糖显示他未发生低血糖发作。使用酶免疫分析试剂盒，在肿瘤操作过程中发现IRI为704微单位/毫升。肿瘤切除后30分钟，其降至9.8微单位/毫升（在正常范围内）。这些数据表明手术是治愈性的，预计残留胰岛素瘤不会再引发低血糖发作。
