Taniai N, Onda M, Tajiri T, Kim T
The First Department of Surgery, Nippon Medical School.
Nihon Shokakibyo Gakkai Zasshi. 1995 Jun;92(6):939-50.
In order to study the changes in distribution of reticuloendothelial function in transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC), the radioactivity of 99mTc-phytate was calculated by the accumulation rate in the organs by means of the single emission computed tomography (SPECT). It was regarded as the reticuloendothelial function in the liver and spleen, and was evaluated independently. Before TAE, significant increases were noted in both splenic activity and splenic volume in the cirrhotic patients, as compared with non-cirrhotic patients. After TAE, the activity in the liver was reduced at the first day after TAE, which returned to the normal level by 5 days. While that in the spleen increased immediately after TAE. After one day of TAE, reticuloendothelial functions of the spleen was significantly higher in the cirrhotic cases then in the non-cirrhotic cases. Furthermore, in the cirrhotic patients, it was significantly higher in the cases embolizated in more than two segments than in those embolizated in one segment only. In conclusion, the reticuloendothelial function of the liver was significantly reduced by the TAE in the cirrhotic patients as compared with non-cirrhotic patients. However the reduced reticuloendothelial function of the liver in the cirrhotic patients was compensated by the increased reticuloendothelial function of the spleen.
为研究经导管动脉栓塞术（TAE）治疗肝细胞癌（HCC）过程中网状内皮系统功能分布的变化，采用单光子发射计算机断层扫描（SPECT）通过器官内放射性药物99mTc-植酸盐的蓄积率计算其放射性。将其视为肝脏和脾脏的网状内皮系统功能，并进行独立评估。TAE术前，与非肝硬化患者相比，肝硬化患者的脾脏活性和脾脏体积均显著增加。TAE术后，肝脏活性在术后第1天降低，5天后恢复至正常水平。而脾脏活性在TAE术后立即升高。TAE术后1天，肝硬化患者脾脏的网状内皮系统功能显著高于非肝硬化患者。此外，在肝硬化患者中，栓塞超过两个节段的患者其网状内皮系统功能显著高于仅栓塞一个节段的患者。总之，与非肝硬化患者相比，TAE使肝硬化患者肝脏的网状内皮系统功能显著降低。然而，肝硬化患者肝脏网状内皮系统功能的降低被脾脏网状内皮系统功能的增加所代偿。
