Ohmoto K, Yamamoto S
Department of Medicine, Kawasaki Medical School, Okayama, Japan.
Hepatogastroenterology. 1998 Jul-Aug;45(22):1082-4.
BACKGROUND/AIMS: Zinc metabolism after transcatheter arterial embolization (TAE) was studied in 15 cases of hepatocellular carcinoma (HCC) with liver cirrhosis (LC).
Serum zinc concentrations, 24-hr urinary excretion of zinc, blood ammonia (NH3) and plasma endotoxin (Et) levels were measured before and one, three and seven days after TAE.
Serum zinc levels one day after TAE were decreased (p<0.05) as compared to those before TAE and then returned to pretreatment values three days or more after TAE. Urinary excretion of zinc increased (p<0.01) one day after TAE, but then returned to the pretreatment value three days after TAE. Although blood NH3 and plasma Et levels increased (P<0.05) the day after TAE, these parameters recovered on the third day.
Decrease in the serum zinc concentration after TAE is considered to be due to changes in the zinc distribution in the body associated with endotoxemia, as well as increased urinary zinc excretion.
背景/目的：对15例伴有肝硬化（LC）的肝细胞癌（HCC）患者行经导管动脉栓塞术（TAE）后的锌代谢情况进行了研究。
在TAE术前、术后1天、3天和7天测量血清锌浓度、24小时尿锌排泄量、血氨（NH3）和血浆内毒素（Et）水平。
与TAE术前相比，TAE术后1天血清锌水平降低（p<0.05），然后在TAE术后3天或更长时间恢复到术前值。TAE术后1天尿锌排泄量增加（p<0.01），但在TAE术后3天恢复到术前值。虽然TAE术后第1天血NH3和血浆Et水平升高（P<0.05），但这些参数在第3天恢复正常。
TAE术后血清锌浓度降低被认为是由于内毒素血症导致体内锌分布改变以及尿锌排泄增加所致。
