Teramoto T, Iwabuchi S, Takatori M, Osada T, Iino S
Second Department of Internal Medicine, St. Marianna University School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 1995 Jun;92(6):960-7.
Serum HCV-RNA levels were determined by newly developed branched DNA probe (bDNA) assay in 87 patients with hepatocellular carcinoma (HCC), compared with 73 patients with chronic hepatitis active and 30 patients with liver cirrhosis. Patients with decompensated liver cirrhosis (LC-d) had a significant lower viremia (mean 3.2Meg.eq./ml, bDNA positive rate; 40%) than chronic hepatitis active (18.0; 64%) and compensated LC (LC-c, 17.9; 80%) (p < 0.05). Those data indicates that HCV replication may decrease as progression of LC. In contrast, there was no difference between the levels of HCC with LC-c (8.2; 85%) and LC-d (6.1; 89%), and their positive rate of bDNA assay were significantly higher than LC-d without HCC (p < 0.01). Therefore, patients undergoing LC in whom serum HCV-RNA sustained high level may correspond to the high risk group of HCC. In HCC of heavy drinker, serum HCV-RNA levels (11.3; 91%) were significantly higher than the levels (4.6; 79%) of HCC without heavy drink (p < 0.05). The result indicates that heavy drink may induced an increase in HCV replication.
采用新开发的分支DNA探针（bDNA）检测法测定了87例肝细胞癌（HCC）患者的血清HCV-RNA水平，并与73例慢性活动性肝炎患者和30例肝硬化患者进行了比较。失代偿期肝硬化（LC-d）患者的病毒血症水平（平均3.2兆当量/毫升，bDNA阳性率40%）显著低于慢性活动性肝炎患者（18.0；64%）和代偿期LC（LC-c，17.9；80%）（p<0.05）。这些数据表明，随着LC的进展，HCV复制可能会减少。相比之下，伴有LC-c的HCC患者（8.2；85%）和伴有LC-d的HCC患者（6.1；89%）之间的水平没有差异，且他们的bDNA检测阳性率显著高于无HCC的LC-d患者（p<0.01）。因此，血清HCV-RNA持续高水平的LC患者可能属于HCC的高危组。在重度饮酒者的HCC中，血清HCV-RNA水平（11.3；91%）显著高于无重度饮酒的HCC患者（4.6；79%）（p<0.05）。结果表明，重度饮酒可能会导致HCV复制增加。
