Kao J H, Lai M Y, Chen P J, Hwang L H, Chen D S
Department of Internal Medicine, National Taiwan University Hospital, Taipei.
J Clin Gastroenterol. 1996 Dec;23(4):280-3. doi: 10.1097/00004836-199612000-00008.
The correlation of serum hepatitis C virus (HCV) titers to the progression of type C chronic liver disease remains controversial. We have investigated the relationship between serum HCV titers and different histological stages of chronic liver disease, including chronic persistent hepatitis (CPH), chronic active hepatitis and/or liver cirrhosis (CAH/LC), and hepatocellular carcinoma (HCC) in 94 well-characterized Taiwanese patients. The mean age of patients in the HCC group was significantly older than those in the CPH and CAH/LC groups, whereas those in the CAH/LC group had the highest mean serum alanine aminotransferase level among the three groups. The prevalence of HCV type 1b increased with the progression of histological severity, and the mean serum titer of the HCC group was significantly higher than that of CPH group. The difference of virus titers between the HCC group and those of the other two groups became more significant when only type 1b virus-infected patients were analyzed. In conclusion, elevated serum HCV titers are more frequently observed among Taiwanese patients with advanced type C chronic liver disease, an association not related to the high prevalence of HCV type 1b infection in such patients.
血清丙型肝炎病毒（HCV）滴度与丙型慢性肝病进展之间的相关性仍存在争议。我们调查了94例特征明确的台湾患者血清HCV滴度与慢性肝病不同组织学阶段之间的关系，这些阶段包括慢性持续性肝炎（CPH）、慢性活动性肝炎和/或肝硬化（CAH/LC）以及肝细胞癌（HCC）。HCC组患者的平均年龄显著高于CPH组和CAH/LC组，而CAH/LC组患者的平均血清丙氨酸转氨酶水平在三组中最高。1b型HCV的流行率随组织学严重程度的进展而增加，HCC组的平均血清滴度显著高于CPH组。当仅分析1b型病毒感染患者时，HCC组与其他两组之间的病毒滴度差异变得更加显著。总之，在台湾晚期丙型慢性肝病患者中更常观察到血清HCV滴度升高，这种关联与此类患者中1b型HCV感染的高流行率无关。
