Nawwar A M, Sherif M F, Barakat N G
Department of Mechanical Engineering, Kuwait University.
J Biomech Eng. 1995 Feb;117(1):53-8. doi: 10.1115/1.2792270.
Compression (or crushing) is used to induce nerve injury in test rats to study nerve degeneration and regeneration. The compression forces could be applied using a variety of techniques developed by several investigators. The lack of precise control of the applied compression may be the source of significant variations among observations. In this study, a Mosquito and dressing forceps were used. The Mosquito forceps was calibrated to determine the tip load corresponding to the clamping position. The dressing forceps was modified, instrumented with strain gauges and calibrated to directly measure the force applied at its tip. These two forceps were used to induce known and controlled nerve compression in 75 male Wistar rats (280-300g). The applied forces were of the order of 40N and 20N, for the Mosquito and dressing forceps, respectively.
在实验大鼠中采用压迫（或挤压）来诱导神经损伤，以研究神经变性和再生。可以使用几位研究者开发的多种技术来施加压迫力。所施加压迫缺乏精确控制可能是观察结果存在显著差异的原因。在本研究中，使用了蚊式钳和敷料镊。对蚊式钳进行校准以确定对应于夹持位置的尖端负荷。对敷料镊进行了改进，安装了应变片并进行校准以直接测量其尖端施加的力。使用这两种镊子在75只雄性Wistar大鼠（体重280 - 300克）中诱导已知且可控的神经压迫。蚊式钳和敷料镊施加的力分别约为40N和20N。
