Galeone F, Giuntoli F, Fiore G, Brunelleschi G, Saba P
Department of Medicine, Hospital of Valdinievole, Pescia, Italy.
J Cardiovasc Pharmacol. 1994;23 Suppl 5:S105-7. doi: 10.1097/00005344-199423005-00023.
Diabetes mellitus is often associated with hypertension and is an additional cardiovascular risk factor. It is therefore important that antihypertensive drugs should have no negative metabolic effects. We present here the results of two distinct studies investigating the clinical efficacy and the metabolic effects of lacidipine in hypertensive patients without concomitant diabetes. Patients in the first study (group A) were hypertensive with non-insulin-dependent diabetes mellitus (NIDDM) and stable blood glucose levels in the 3 months before entering the study. Patients in the second study (group B) were hypertensive without diabetes mellitus. Before the commencement of the study, antihypertensive treatment was discontinued in all patients for a 4-week washout period, followed by 4 weeks of run-in with placebo. Patients were then treated with lacidipine (4 mg o.d.) for 6 months. After 1-2 months, the dose was doubled in patients with uncontrolled blood pressure. Every 2 months, lipid and carbohydrate metabolism were investigated by blood chemistry analyses. The results demonstrate that lacidipine 4-8 mg o.d. is efficacious and well tolerated in hypertensive patients, even in the presence of diabetes mellitus.
糖尿病常与高血压相关，是一个额外的心血管危险因素。因此，抗高血压药物不应有负面代谢影响，这一点很重要。我们在此展示两项不同研究的结果，这些研究调查了拉西地平在无伴发糖尿病的高血压患者中的临床疗效和代谢影响。第一项研究（A组）的患者患有高血压且伴有非胰岛素依赖型糖尿病（NIDDM），在进入研究前3个月血糖水平稳定。第二项研究（B组）的患者患有高血压但无糖尿病。在研究开始前，所有患者停用抗高血压治疗4周的洗脱期，随后用安慰剂进行4周的导入期。然后患者接受拉西地平（每日4毫克）治疗6个月。1 - 2个月后，血压未得到控制的患者剂量加倍。每2个月通过血液化学分析调查脂质和碳水化合物代谢情况。结果表明，每日服用4 - 8毫克拉西地平对高血压患者有效且耐受性良好，即使存在糖尿病也是如此。
