Adachi Y, Kido A, Mori M, Matsushima T, Shimono R, Inoue T, Sugimachi K
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Surg Oncol. 1995 Jul;59(3):177-80. doi: 10.1002/jso.2930590308.
The prognostic value of nuclear DNA content and argyrophilic nucleolar organizer regions (AgNOR) is still controversial in colorectal cancer. Sixty patients with colorectal cancer were studied by flow cytometric DNA analysis and AgNOR measurement, and their prognostic significance was tested. DNA index was closely linked to depth of invasion and lymph node metastasis, while AgNOR count did not correlate with such parameters. The survival curve was strongly influenced by depth of invasion, lymph node metastasis, and Dukes' stage but was not affected by DNA ploidy and AgNOR count. These results indicate that neither DNA ploidy nor AgNOR count correlates with survival of patients, although DNA ploidy is linked to progression of colorectal cancer.
在结直肠癌中，细胞核DNA含量和嗜银核仁组成区（AgNOR）的预后价值仍存在争议。通过流式细胞术DNA分析和AgNOR测量对60例结直肠癌患者进行了研究，并检验了它们的预后意义。DNA指数与浸润深度和淋巴结转移密切相关，而AgNOR计数与这些参数无关。生存曲线受浸润深度、淋巴结转移和Dukes分期的强烈影响，但不受DNA倍体和AgNOR计数的影响。这些结果表明，尽管DNA倍体与结直肠癌的进展有关，但DNA倍体和AgNOR计数均与患者的生存率无关。
