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Glycinergic inhibition of spontaneously active guinea-pig medial vestibular nucleus neurons in vitro.

作者信息

Lapeyre P N, De Waele C

机构信息

Laboratoire de Physiologie de la Perception et de l'Action, Collège de France CNRS, UMR C9950, Paris.

出版信息

Neurosci Lett. 1995 Mar 31;188(3):155-8. doi: 10.1016/0304-3940(95)11418-v.

DOI:10.1016/0304-3940(95)11418-v
PMID:7609898
Abstract

Effects of glycine on the spontaneous activity of medial vestibular nucleus (MVN) neurons recorded extracellularly from guinea-pig brainstem slices were investigated. Glycine produced a dose-dependent decrease in the resting discharge rate of all MVN neurons tested, with a mean EC50 of 3.9 x 10(-4) M. The inhibitory effect of glycine was reversibly blocked by strychnine and persisted in a low calcium/high magnesium-containing saline solution. These findings suggest the existence of a direct strychnine-sensitive inhibitory effect of glycine on guinea-pig MVN neurons.

摘要

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