Boarder M R, Weisman G A, Turner J T, Wilkinson G F
Department of Cell Physiology and Pharmacology, University of Leicester, UK.
Trends Pharmacol Sci. 1995 Apr;16(4):133-9. doi: 10.1016/s0165-6147(00)89001-x.
Nucleotides such as ATP and ADP act as intercellular messengers and exert a widespread influence on cellular function by acting on a variety of cell surface receptors. Until recently, progress has been restrained, in part, by a lack of cloned receptors. Now, however, the successful cloning of a variety of P2 purinoceptors is holding out the prospect of rapid advances in the understanding of this diverse group of receptors and the potent therapeutic resource they represent. In this article, Michael Boarder and colleagues summarize the findings of recent cloning studies, and assess the impact of these on the understanding of the function of the G protein-coupled P2 purinoceptors in several types of cells and tissues.
三磷酸腺苷（ATP）和二磷酸腺苷（ADP）等核苷酸作为细胞间信使，通过作用于多种细胞表面受体，对细胞功能产生广泛影响。直到最近，研究进展在一定程度上受到缺乏克隆受体的限制。然而，现在多种P2嘌呤能受体的成功克隆为深入了解这一多样的受体群体及其所代表的强大治疗资源带来了快速进展的前景。在本文中，迈克尔·博德和同事总结了近期克隆研究的结果，并评估了这些结果对理解G蛋白偶联P2嘌呤能受体在几种类型的细胞和组织中的功能的影响。
