Otto T, Goepel M, Recker F, Rübben H
Urologische Klinik, Universitätsklinikum, GHS, Essen.
Urologe A. 1995 May;34(3):208-11.
Histopathological and clinical parameters are of limited value in characterization of the individual course of disease in bladder cancer patients. Down-regulation of E-cadherin, an intercellular adhesion molecule, and upregulation of autocrine motility factor receptor (AMFR) expression have been shown to play a part in tumour cell invasion and metastasis. In a retrospective analysis concerning 95 different bladder specimens and a prospective study in 100 bladder cancer patients, reduction in E-cadherin concomitantly with an increase in AMFR expression was associated with a poor prognosis. The dual use of these two antigens may improve early diagnosis of high-risk bladder cancer patients and influence treatment decisions.
组织病理学和临床参数在表征膀胱癌患者个体病程方面价值有限。细胞间粘附分子E-钙粘蛋白的下调以及自分泌运动因子受体（AMFR）表达的上调已被证明在肿瘤细胞侵袭和转移中起作用。在一项针对95个不同膀胱标本的回顾性分析以及一项对100例膀胱癌患者的前瞻性研究中，E-钙粘蛋白减少同时AMFR表达增加与预后不良相关。这两种抗原的联合使用可能会改善高危膀胱癌患者的早期诊断并影响治疗决策。
