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使用“奥地利标准系列”进行斑贴试验——流行病学测试值与结果

[Patch testing with the "Austrian standard series"--epidemiologic test values and results].

作者信息

Kränke B, Binder M, Derhaschnig J, Komericki P, Pirkhammer D, Ziegler V, Aberer W

机构信息

Universitäts-Hautklinik, Graz.

出版信息

Wien Klin Wochenschr. 1995;107(11):323-30.

PMID:7610657
Abstract

Patch testing for contact allergies is routinely performed by applying a "standard series" of the most frequently occurring contact allergens. Internationally "established" standard series have to be adapted to country- and population-specific factors (i.e., distribution of gender and age, occupational behavior, environmental factors etc.). In 1992 and 1993 altogether 11,690 patients were patch tested in 14 Austrian test centers with the "Austrian standard patch test series" as recommended by the working group "Contact Allergy" of the Austrian Society of Dermatology. Altogether data on 11,544 patients were complete and are analyzed in this study. 71.5% of the test population were female with an average age of 39 years, whereas the male patients had an average age of 40 years. 38.1% of the patients were younger than 30 years, 47.8% were in the group ranging from 31 to 60 years and 14% of the tested patients were older than 60 years. Cutaneous sensitization was found in 51% of the people tested with the "Austrian standard series". This proportion varied between 40.8 and 61.4% from center to center (with more than 100 tested persons). 15 (60%) of the 25 test substances in 1992 and 17 (68%) in 1993 surpassed the limit of a sensitization frequency of 1%. The "hit list" of substances did not differ qualitatively from those of other international studies, with only one remarkable, well described "Austrian-specific" exception, namely the mercury-containing thiomersal (second place).(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

接触性过敏的斑贴试验通常是通过应用一系列最常见的接触性变应原进行的。国际上“既定”的标准系列必须根据国家和人群的特定因素(即性别和年龄分布、职业行为、环境因素等)进行调整。1992年和1993年,共有11690名患者在奥地利的14个检测中心接受了斑贴试验,使用的是奥地利皮肤病学会“接触性过敏”工作组推荐的“奥地利标准斑贴试验系列”。本研究共分析了11544名患者的完整数据。受试人群中71.5%为女性,平均年龄39岁,男性患者平均年龄40岁。38.1%的患者年龄小于30岁,47.8%的患者年龄在31至60岁之间,14%的受试患者年龄大于60岁。使用“奥地利标准系列”进行检测的人群中,51%发现有皮肤致敏现象。各中心之间这一比例在40.8%至61.4%之间(受试人数超过100人)。1992年25种受试物质中有15种(60%)、1993年有17种(68%)超过了致敏频率1%的限值。该物质清单在性质上与其他国际研究的清单并无差异,只有一个显著的、描述详尽的“奥地利特有”例外,即含汞的硫柳汞(位居第二)。(摘要截选至250词)

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