Liu Y Q, Zhao B, Zhuang L H, Fan W X
Department of Dermatology, First Affiliated Hospital of Xuzhou Medical College, P.R. China.
Am J Contact Dermat. 1997 Sep;8(3):141-3.
The patch test has become the standard method of investigating patients with allergic contact dermatitis. Many countries have developed standard screening allergens to make patch testing more efficient. A series of the Chinese Standard Screening Allergens were studied and modified.
This study investigated the frequency of contact allergies in suspected allergic contact dermatitis and tested the practicality of the Chinese Standard Screening Patch Test Allergens.
A total of 1,135 patients suspected of having allergic contact dermatitis were patch tested. Three hundred twelve (27.5%) were men, and their age ranged from 2 to 75 years old (mean age, 34.3 years), 823 (72.5%) were women, and their age ranged from 2 to 76 years old (mean age, 33.0 years). Nanjing Medical University supplied the Chinese Standard Screening Allergens and Finn-Chamber. All patients were patch tested according to the Chinese Standard Screening Patch Test Allergens with Finn-Chamber the protocol as established by the International Contact Dermatitis Research Group (ICDRG).
From the 1,135 patients suspected to have allergic contact dermatitis, 650 (57.3%) had at least one positive reaction. Nineteen (95%) of the Chinese Standard Screening Patch Test Allergens had positive reactions higher than 1%. Of 485 patients with negative reaction to the Standard Allergens, 106 patients were tested with other suspected contactants according to history. Thirty-nine (36.8%) had positive reactions to the contactants they provided. The total positive rate therefore increased by 3.4%.
Our study results indicate that the Chinese Standard Screening Patch Test Allergens are suitable for use in routine clinic in China.
斑贴试验已成为调查过敏性接触性皮炎患者的标准方法。许多国家已开发出标准筛查变应原，以使斑贴试验更高效。对一系列中国标准筛查变应原进行了研究和改进。
本研究调查疑似过敏性接触性皮炎患者中接触性过敏的频率，并测试中国标准筛查斑贴试验变应原的实用性。
对总共1135例疑似过敏性接触性皮炎患者进行斑贴试验。其中男性312例（27.5%），年龄2至75岁（平均年龄34.3岁）；女性823例（72.5%），年龄2至76岁（平均年龄33.0岁）。南京医科大学提供中国标准筛查变应原和芬兰小室。所有患者均按照国际接触性皮炎研究组（ICDRG）制定的方案，使用芬兰小室，依据中国标准筛查斑贴试验变应原进行斑贴试验。
在1135例疑似过敏性接触性皮炎患者中，650例（57.3%）至少有1次阳性反应。中国标准筛查斑贴试验变应原中有19种（95%）阳性反应高于1%。在对标准变应原呈阴性反应的485例患者中，根据病史对106例患者进行了其他疑似接触物的检测。其中39例（36.8%）对其提供的接触物呈阳性反应。因此总阳性率提高了3.4%。
我们的研究结果表明，中国标准筛查斑贴试验变应原适用于中国的常规临床应用。
