Verschuur H P, Rijksen G, Slootweg P J, Hordijk G J
Department of Otorhinolaryngology, University Hospital Utrecht, The Netherlands.
Acta Otolaryngol. 1995 Mar;115(2):326-7. doi: 10.3109/00016489509139321.
Protein tyrosine kinases (PTK) and protein tyrosine phosphatases (PTPase) activity in tumor tissue, obtained from 107 patients with squamous cell carcinoma of the upper aerodigestive tract, was determined. In 79 patients samples were also taken from a histologically proven non-tumourous part of the mucosa. In this extensive study we confirmed our previous findings of increased enzyme activities (cytosol PTK, membranes PTK, cytosol PTPase) in non-tumour tissues compared with control tissues. These biochemical changes suggesting a premalignant mucosa could not be correlated to a higher probability of secondary tumours.
测定了107例上消化道鳞状细胞癌患者肿瘤组织中的蛋白酪氨酸激酶（PTK）和蛋白酪氨酸磷酸酶（PTPase）活性。在79例患者中，还从组织学证实的黏膜非肿瘤部分采集了样本。在这项广泛的研究中，我们证实了之前的发现，即与对照组织相比，非肿瘤组织中的酶活性（胞质溶胶PTK、膜PTK、胞质溶胶PTPase）增加。这些表明黏膜处于癌前状态的生化变化与继发性肿瘤的较高发生率并无关联。
