克罗恩病中凝血因子XIII缺乏症
Deficiency of blood coagulation factor XIII in Crohn's disease.
作者信息
Oshitani N, Kitano A, Hara J, Suzuki N, Aoki T, Yasuda K, Watanabe Y, Obayashi M, Obata A, Nakamura S
机构信息
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
出版信息
Am J Gastroenterol. 1995 Jul;90(7):1116-8.
OBJECTIVE
Refractory fistula formation is one of most intractable complications in Crohn's disease. Recently, the role of blood coagulation Factor XIII has been recognized as an important wound-healing factor. We investigated the plasma concentration and functional activity of blood coagulation Factor XIIIa, active subunit of the Factor XIII, in patients with Crohn's disease and in healthy volunteers.
METHODS
Peripheral blood was obtained from 24 patients with Crohn's disease and from 10 healthy volunteers. The functional activity of Factor XIIIa was measured by its transglutaminase activity, and plasma concentration was measured by the immunoelectrophoresis method.
RESULTS
The differences in Crohn's disease patients and healthy volunteers were not significant. However, Crohn's disease patients with fistula had significantly lower functional activity than Crohn's disease patients without fistula.
CONCLUSIONS
The deficiency in this wound-healing factor might be one reason for refractory fistulas in Crohn's disease, and supplementation of the factor might be useful therapeutically.
目的
难治性瘘管形成是克罗恩病最棘手的并发症之一。近来，凝血因子XIII被认为是一种重要的伤口愈合因子。我们研究了克罗恩病患者和健康志愿者血浆中凝血因子XIIIa（因子XIII的活性亚基）的浓度及功能活性。
方法
采集24例克罗恩病患者和10名健康志愿者的外周血。通过转谷氨酰胺酶活性测定因子XIIIa的功能活性，采用免疫电泳法测定血浆浓度。
结果
克罗恩病患者与健康志愿者之间的差异不显著。然而，有瘘管的克罗恩病患者的功能活性显著低于无瘘管的克罗恩病患者。
结论
这种伤口愈合因子的缺乏可能是克罗恩病难治性瘘管形成的原因之一，补充该因子可能具有治疗作用。
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