[5'-脱氧-5-氟尿苷（5'-DFUR）对人胃正常组织和肿瘤组织中嘧啶核苷磷酸化酶（pyNPase）活性的影响]
[Effect of 5'-deoxy-5-fluorouridine (5'-DFUR) on the activity of pyrimidine nucleoside phosphorylase (pyNPase) in normal and tumor tissues of human stomach].
作者信息
Kimura T, Kobayashi T, Nakaya Y, Iida T, Uchimura M, Murohisa B, Nagashima T, Matsumoto Y, Kitamura H, Shibata M
机构信息
First Dept. of Surgery, Hamamatsu University School of Medicine.
出版信息
Gan To Kagaku Ryoho. 1995 Jul;22(8):1051-6.
PyNPase (pyrimidine nucleoside phosphorylase) activity and IL-1 alpha were measured in normal and tumor tissues of the specimens resected from gastric cancer patients who had been divided into two groups; one given preoperative 5'-DFUR (oral administration at a mean dose of 10.0 g) and one not given 5'-DFUR (control). PyNPase activities in both groups were higher in tumor than in normal tissues (p = 0.0001), but, less in tumor tissue of the preoperative administration group than the controls (p = 0.0376). IL-1 alpha levels in both groups were higher in tumor than in normal tissues (p < 0.01). Multiple regression analysis of the results showed that IL-1 alpha strongly influenced on PyNPase activity in tumor tissues (higher IL-1 alpha levels resulted in higher PyNPase activities in tumor tissues) (p = 0.0334).
对胃癌患者切除标本的正常组织和肿瘤组织进行了嘧啶核苷磷酸化酶（PyNPase）活性及白细胞介素-1α（IL-1α）的检测。这些患者被分为两组，一组术前给予5'-脱氧氟尿苷（5'-DFUR，平均口服剂量10.0 g），另一组未给予5'-DFUR（对照组）。两组肿瘤组织中的PyNPase活性均高于正常组织（p = 0.0001），但术前给药组肿瘤组织中的PyNPase活性低于对照组（p = 0.0376）。两组肿瘤组织中的IL-1α水平均高于正常组织（p < 0.01）。对结果进行的多元回归分析显示，IL-1α对肿瘤组织中的PyNPase活性有强烈影响（肿瘤组织中IL-1α水平越高，PyNPase活性越高）（p = 0.0334）。
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