Nemoto R, Nakamura I, Uchida K, Harada M
Dept. of Urology, Tottori Prefectural Central Hospital.
Gan To Kagaku Ryoho. 1995 Jun;22 Suppl 2:153-7.
The relationship between interphase cytogenetics and the DNA index measuring SCM of bladder cancer was investigated in 17 patients with bladder tumor. By in situ hybridization, the copy number of chromosomes 1, 7, 10, 11, 17, 18, X and Y was detected. The percentage of hyperdiploid cells for chromosomes 7 and 17 was highly correlated with the increasing DNA index. Since a high DNA index is both indicative of more aggressive tumor behavior and a worse prognosis, these findings suggest that the percentage of hyperdiploid cells, especially for chromosome 7 and 17, may be highly predictive of bladder tumor aggressiveness.
对17例膀胱肿瘤患者研究了间期细胞遗传学与测量膀胱癌SCM的DNA指数之间的关系。通过原位杂交，检测了1、7、10、11、17、18、X和Y染色体的拷贝数。7号和17号染色体超二倍体细胞的百分比与DNA指数的增加高度相关。由于高DNA指数既表明肿瘤行为更具侵袭性，预后也更差，这些发现提示超二倍体细胞的百分比，尤其是7号和17号染色体的，可能高度预测膀胱肿瘤的侵袭性。
