Varache-Lembège M, Nuhrich A, Renard P, Duboudin F, Vercauteren J, Devaux G
Laboratoire de Pharmacie chimique et Chimie thérapeutique, U.F.R. des Sciences pharmaceutiques, Université de Bordeaux II, France.
Arch Pharm (Weinheim). 1995 May;328(5):417-24. doi: 10.1002/ardp.19953280505.
Some new oximinoalkanoic (n = 2,3,4) esters and acids derived from methoxyphenylthienyl ketones have been synthesized and evaluated in vitro for their inhibitory effects on arachidonic acid-induced human platelet aggregation. Of the eighteen oximinoethers tested the most active derivatives, which were four times more active as aspirin, belonged to the para methoxy series with Z configuration and n = 2 or 3.
已经合成了一些由甲氧基苯基噻吩基酮衍生的新型肟基链烷酸（n = 2,3,4）酯和酸，并在体外评估了它们对花生四烯酸诱导的人血小板聚集的抑制作用。在所测试的18种肟基醚中，活性最高的衍生物（活性是阿司匹林的四倍）属于具有Z构型且n = 2或3的对甲氧基系列。
