肿瘤坏死因子-α增强小鼠三叉神经节中潜伏单纯疱疹病毒的重新激活和复制
Enhancement by TNF-alpha of reactivation and replication of latent herpes simplex virus from trigeminal ganglia of mice.
作者信息
Walev I, Podlech J, Falke D
机构信息
Division of Experimental Virology, Johannes-Gutenberg-University, Mainz, Federal Republic of Germany.
出版信息
Arch Virol. 1995;140(6):987-92. doi: 10.1007/BF01315409.
The influence of tumor-necrosis-factor-alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukine-1 (IL-1) and IL-3 on the in vitro reactivation frequency and replication rate of trigeminal ganglia of mice latently infected with herpes simplex virus (HSV) strain KOS was studied. It could be demonstrated that TNF-alpha and possibility GM-CSF, but not IL-1 and IL-3, enhanced the reactivation frequency and replication of HSV. Interferon alpha/beta (IFN alpha/beta) prevented reactivation and replication.
研究了肿瘤坏死因子-α（TNF-α）、粒细胞巨噬细胞集落刺激因子（GM-CSF）、白细胞介素-1（IL-1）和IL-3对潜伏感染单纯疱疹病毒（HSV）KOS株的小鼠三叉神经节体外再激活频率和复制率的影响。结果表明，TNF-α以及可能的GM-CSF可增强HSV的再激活频率和复制，而IL-1和IL-3则无此作用。α/β干扰素（IFNα/β）可阻止再激活和复制。
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