Ferraz H B, De Andrade L A, Silva S M, Borges V, Rocha M S
Disciplina de Neurologia, Escola Paulista de Medicina, São Paulo, Brasil.
Arq Neuropsiquiatr. 1994 Dec;52(4):466-70. doi: 10.1590/s0004-282x1994000400002.
The coexistence of tremor and dystonia is usually seen but there is not a satisfactory explanation for it. Some consider that essential tremor (ET) and idiopathic dystonia (ID) may be genetically linked. To clarify this relationship we evaluated the frequency of postural hand tremor in ID and symptomatic dystonia (SD) patients. We studied the records of patients with dystonia seen in our Movement Disorders Unit. ID was considered when there was no other neurological abnormality in the examination aside from dystonia, normal laboratorial tests and neuroimaging related to dystonia, and a negative past history for any known cause for it, except for genetic predisposition. We analyzed the clinical characteristics of dystonia and the occurrence of postural tremor. We collected 185 patients, being 120 with ID and 65 with SD. Tremor was seen in 27 (22.5%) of ID and 14 (21.5%) of SD. Tremor was present in either focal, segmental or generalized dystonia in both ID and SD. Family history for ET was absent in all patients. The similar frequency of tremor in ID and SD patients suggests that the pathophysiologic derangement resulting in dystonia can favor the development of tremor.
震颤和肌张力障碍常同时出现,但对此尚无令人满意的解释。一些人认为特发性震颤(ET)和特发性肌张力障碍(ID)可能存在遗传联系。为了阐明这种关系,我们评估了ID和症状性肌张力障碍(SD)患者中姿势性手部震颤的发生率。我们研究了在我们运动障碍科就诊的肌张力障碍患者的记录。当除肌张力障碍外,检查中无其他神经学异常、与肌张力障碍相关的实验室检查和神经影像学检查正常,且除遗传易感性外无任何已知病因的既往史时,诊断为ID。我们分析了肌张力障碍的临床特征和姿势性震颤的发生情况。我们收集了185例患者,其中120例为ID患者,65例为SD患者。ID患者中有27例(22.5%)出现震颤,SD患者中有14例(21.5%)出现震颤。ID和SD患者的局灶性、节段性或全身性肌张力障碍中均出现震颤。所有患者均无ET家族史。ID和SD患者中震颤发生率相似,提示导致肌张力障碍的病理生理紊乱可能有利于震颤的发生。