女性纤维肌痛。丘脑和尾状核区域脑血流异常与低疼痛阈值水平相关。

Fibromyalgia in women. Abnormalities of regional cerebral blood flow in the thalamus and the caudate nucleus are associated with low pain threshold levels.

作者信息

Mountz J M, Bradley L A, Modell J G, Alexander R W, Triana-Alexander M, Aaron L A, Stewart K E, Alarcón G S, Mountz J D

机构信息

Department of Radiology, University of Alabama Medical Center, Birmingham 35233, USA.

出版信息

Arthritis Rheum. 1995 Jul;38(7):926-38. doi: 10.1002/art.1780380708.

DOI:10.1002/art.1780380708

PMID:7612042

Abstract

OBJECTIVE

To determine if regional cerebral blood flow (rCBF) in the left and right hemithalami or the left and right heads of the caudate nucleus is abnormal in women with fibromyalgia (FM).

METHODS

Resting-state rCBF in the hemithalami and left and right heads of the caudate nucleus of 10 untreated women with FM and 7 normal control women was measured by single-photon-emission computed tomography. Pain threshold levels at tender and control points also were assessed in both the women with FM and the controls.

RESULTS

The rCBF in the left and right hemithalami and the left and right heads of the caudate nucleus was significantly lower in women with FM than in normal controls (P = 0.01, P = 0.003, P = 0.01, and P = 0.02, respectively). Compared with controls, the women with FM also were characterized by significantly lower cortical rCBF (P = 0.001) and lower pain threshold levels at both tender points (P = 0.0001) and control points (P = 0.0001).

CONCLUSION

The findings of low rCBF and generalized low pain thresholds support the hypothesis that abnormal pain perception in women with FM may result from a functional abnormality within the central nervous system.

摘要

目的

确定纤维肌痛（FM）女性患者左右丘脑或左右尾状核头部的局部脑血流量（rCBF）是否异常。

方法

通过单光子发射计算机断层扫描测量10名未经治疗的FM女性患者和7名正常对照女性的丘脑及左右尾状核头部的静息态rCBF。还评估了FM女性患者和对照者在压痛点和对照点的疼痛阈值水平。

结果

FM女性患者左右丘脑及左右尾状核头部的rCBF显著低于正常对照（分别为P = 0.01、P = 0.003、P = 0.01和P = 0.02）。与对照者相比，FM女性患者的特征还包括皮质rCBF显著降低（P = 0.001），压痛点（P = 0.0001）和对照点（P = 0.0001）的疼痛阈值水平均较低。