Wolfe F, Ross K, Anderson J, Russell I J
Arthritis Research and Clinical Centers (St. Francis Research Institute, Wichita, KS 67214.
J Rheumatol. 1995 Jan;22(1):151-6.
To investigate relationships between sex, pain threshold and fibromyalgia (FM) symptoms in the general population.
Data were obtained from a randomized populations survey of 3,006 persons in Wichita, KS and a subsample of 391 who completed a detailed interview and had an examination. Tender point counts, dolorimetry scores, clinical and psychological variables were measured.
Dolorimetry scores were 2.04 kg/cm (1.42-2.66) lower in women than men, and women were almost 10 times more likely to have 11 tender points [OR 9.6 (2.00-46.3)] than men. Women are also more likely to have FM symptoms than men: "Pain all over," [OR 3.94 (1.34-11.38)], sleep disturbance [OR 3.06 (1.45-6.46)], fatigue [OR 4.52 (2.03-10.09)], and irritable bowel syndrome [OR 5.23 (1.83-14.96)]. Tender point counts are more correlated with FM symptoms than dolorimetry scores.
Symptoms of FM are correlated with pain threshold in the general population, but tender point counts correlate better than dolorimetry. These 2 measures of pain threshold assay different but overlapping factors. Pain threshold is lower in women; and women have more FM symptoms. Decreased pain threshold correlates with all of the symptoms of FM, even in those who do not meet criteria for the syndrome. This suggests that decreased pain threshold, as measured by the tender point counts, is an intrinsically important aspect of patient distress, regardless of the extent and kind of concomitant disease; and that much can be learned about patients by employing this examination.
研究普通人群中性别、疼痛阈值与纤维肌痛（FM）症状之间的关系。
数据来自堪萨斯州威奇托市对3006人的随机人群调查，以及391名完成详细访谈并接受检查的子样本。测量了压痛点计数、痛觉测量分数、临床和心理变量。
女性的痛觉测量分数比男性低2.04 kg/cm（1.42 - 2.66），女性出现11个压痛点的可能性几乎是男性的10倍[比值比（OR）9.6（2.00 - 46.3）]。女性比男性更易出现FM症状：“全身疼痛”[OR 3.94（1.34 - 11.38）]、睡眠障碍[OR 3.06（1.45 - 6.46）]、疲劳[OR 4.52（2.03 - 10.09）]和肠易激综合征[OR 5.23（1.83 - 14.96）]。压痛点计数比痛觉测量分数与FM症状的相关性更强。
在普通人群中，FM症状与疼痛阈值相关，但压痛点计数的相关性优于痛觉测量。这两种疼痛阈值测量方法检测的因素不同但有重叠。女性的疼痛阈值较低，且女性有更多的FM症状。疼痛阈值降低与FM的所有症状相关，即使在不符合该综合征标准的人群中也是如此。这表明，通过压痛点计数测量的疼痛阈值降低是患者痛苦的一个内在重要方面，无论伴随疾病的程度和类型如何；并且通过采用这种检查可以了解患者的很多情况。
