Synthesis and antifungal activities of some new triazolylacetophenone derivatives.

In this study some alpha-(1,2,4-triazolyl)acetophenone derivatives were synthesized by the condensation of various triazole and alpha-bromoacetophenone rings. The structures of the compounds have been elucidated by UV, IR, 1H-NMR, mass spectra and elementary analysis. The in vitro antifungal activity of the compounds were investigated against some yeast-like fungi (Candida albicans, C. parapsilosis, C. stellatoidea and C. pseudotropicalis) and moulds such as Trichophyton rubrum and T. mentagrophytes by the tube dilution method and MIC (minimal inhibitory concentration), MFC (minimal fungicidal concentration) values were determined. Compound A16 was significantly more effective than the other compounds. The results obtained for antifungal activity against moulds were not significant.