Duquesnoy R J, Pedersen G M
Cancer Res. 1979 Feb;39(2 Pt 1):415-8.
Administration of ovine growth hormone to young C3Hf mice inhibited Gross passage A virus-induced leukemogenesis as manifested by a delayed onset and a lower incidence of thymus leukemia. These results can be interpreted that growth hormone inhibited thymus-dependent leukemogenesis perhaps through thymotrophic influences which prevented or delayed the thymus involution believed to be essential for leukemia change. In female but not in male Gross passage A virus-infected mice, development of a thymus-independent leukemia appeared to be promoted by growth hormone.
给幼小的C3Hf小鼠注射绵羊生长激素，可抑制格罗斯A病毒诱发的白血病发生，表现为胸腺白血病的发病延迟和发病率降低。这些结果可以解释为，生长激素可能通过营养胸腺的作用抑制依赖胸腺的白血病发生，这种作用可预防或延缓胸腺退化，而胸腺退化被认为是白血病发生所必需的。在感染格罗斯A病毒的雌性小鼠而非雄性小鼠中，生长激素似乎促进了非胸腺依赖性白血病的发展。
