进行性系统性硬化症肺部表现的免疫抑制治疗。

Immunosuppressive treatment of the pulmonary manifestations of progressive systemic sclerosis.

作者信息

Vallance D K, Lynch J P, McCune W J

机构信息

Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0358, USA.

出版信息

Curr Opin Rheumatol. 1995 May;7(3):174-82. doi: 10.1097/00002281-199505000-00004.

DOI:10.1097/00002281-199505000-00004

PMID:7612408

Abstract

In this article, we review recent studies on the use of immunosuppressive agents in autoimmune diseases, especially cyclophosphamide. In addition, we begin with a special section on the treatment of scleroderma lung disease, including controversies regarding the indications for immunosuppressive therapy. Scleroderma lung disease is justifiably regarded as one of the "frontiers of medicine" because of its gravity, its often rapidly progressive nature, and the urgency with which improved therapy is needed.

摘要

在本文中，我们回顾了近期关于免疫抑制剂在自身免疫性疾病中的应用的研究，尤其是环磷酰胺。此外，我们开篇设有一个关于硬皮病肺病治疗的特别章节，包括免疫抑制治疗指征方面的争议。硬皮病肺病因其严重性、通常快速进展的特性以及对改善治疗的迫切需求，理所当然地被视为“医学前沿领域”之一。