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Serum LL-37 levels correlate with the efficacy of i.v. cyclophosphamide pulse for skin sclerosis and interstitial lung disease in systemic sclerosis.

作者信息

Takahashi Takehiro, Asano Yoshihide, Taniguchi Takashi, Yoshizaki Ayumi, Sato Shinichi

机构信息

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

出版信息

J Dermatol. 2017 Apr;44(4):468-469. doi: 10.1111/1346-8138.13553.

DOI:10.1111/1346-8138.13553
PMID:28378437
Abstract
摘要

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1
Serum LL-37 levels correlate with the efficacy of i.v. cyclophosphamide pulse for skin sclerosis and interstitial lung disease in systemic sclerosis.
J Dermatol. 2017 Apr;44(4):468-469. doi: 10.1111/1346-8138.13553.
2
Prediction of therapeutic response before and during i.v. cyclophosphamide pulse therapy for interstitial lung disease in systemic sclerosis: A longitudinal observational study.系统性硬皮病间质性肺病患者静脉环磷酰胺冲击治疗前和治疗期间治疗反应的预测：一项纵向观察性研究。
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Rapid alteration of serum interleukin-6 levels may predict the reactivity of i.v. cyclophosphamide pulse therapy in systemic sclerosis-associated interstitial lung disease.血清白细胞介素-6 水平的快速变化可能预测系统性硬皮病相关间质性肺病静脉注射环磷酰胺冲击治疗的反应性。
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Dynamics of serum angiopoietin-2 levels correlate with efficacy of intravenous pulse cyclophosphamide therapy for interstitial lung disease associated with systemic sclerosis.血清血管生成素-2 水平的动态变化与静脉注射脉冲环磷酰胺治疗系统性硬皮病相关间质性肺病的疗效相关。
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Immunosuppressive treatment of the pulmonary manifestations of progressive systemic sclerosis.进行性系统性硬化症肺部表现的免疫抑制治疗。
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Clinical significance of monitoring serum adiponectin levels during intravenous pulse cyclophosphamide therapy in interstitial lung disease associated with systemic sclerosis.监测静脉脉冲环磷酰胺治疗系统性硬皮病相关间质性肺病患者血清脂联素水平的临床意义。
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Successful treatment with rituximab in a Japanese patient with systemic sclerosis-associated interstitial lung disease resistant to oral steroid and cyclophosphamide.利妥昔单抗成功治疗一名对口服类固醇和环磷酰胺耐药的日本系统性硬化症相关间质性肺病患者。
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Treatment with cyclophosphamide i.v. pulse therapy is an option for effective treatment of skin fibrosis in patients with early systemic sclerosis.静脉注射环磷酰胺脉冲治疗是治疗早期系统性硬皮病患者皮肤纤维化的有效方法。
Rheumatology (Oxford). 2020 Jul 1;59(7):1550-1555. doi: 10.1093/rheumatology/kez487.

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Cyclophosphamide Pulse Therapy Normalizes Vascular Abnormalities in a Mouse Model of Systemic Sclerosis Vasculopathy.环磷酰胺脉冲疗法可使系统性硬化症血管病变小鼠模型的血管异常正常化。
J Invest Dermatol. 2019 May;139(5):1150-1160. doi: 10.1016/j.jid.2018.11.016. Epub 2018 Nov 30.