Ito N, Saito A, Kayashima S, Kimura J, Kuriyama T, Nagata N, Arai T, Kikuchi M
Central Research Laboratories, NEC Corporation, Kanagawa, Japan.
Front Med Biol Eng. 1995;6(4):269-80.
A transcutaneous blood glucose monitoring system consists of an ion-sensitive field-effect transistor (ISFET) glucose sensor unit and a suction effusion fluid (SEF) collecting unit. The SEF is directly collected by a weak suction (400 mmHg absolute pressure) through the skin from which the corneum layer of the epidermis has been previously removed. An ISFET glucose sensor unit is able to measure glucose concentrations in a microliter order sampling volume. The system was applied to three diabetic patients during a 75 g oral glucose tolerance test for monitoring blood glucose levels. During the experiments, glucose changes in the SEF followed actual blood glucose levels with 10 min delays. Results suggest the feasibility of utilizing quasi-continuous, transcutaneous blood glucose monitoring for individual patients with various diabetic histories or diabetic complications.
一种经皮血糖监测系统由离子敏感场效应晶体管（ISFET）葡萄糖传感器单元和抽吸渗出液（SEF）收集单元组成。通过对先前已去除表皮角质层的皮肤施加弱吸力（绝对压力400 mmHg）直接收集SEF。ISFET葡萄糖传感器单元能够测量微升量级采样体积中的葡萄糖浓度。该系统在75 g口服葡萄糖耐量试验期间应用于三名糖尿病患者以监测血糖水平。在实验过程中，SEF中的葡萄糖变化跟随实际血糖水平，但有10分钟的延迟。结果表明，对于具有各种糖尿病病史或糖尿病并发症的个体患者，利用准连续经皮血糖监测具有可行性。
