术中使用丝裂霉素C治疗原发性翼状胬肉的前瞻性试验。
Prospective trial of intraoperative mitomycin C in the treatment of primary pterygium.
作者信息
Cano-Parra J, Diaz-Llopis M, Maldonado M J, Vila E, Menezo J L
机构信息
Department of Ophthalmology, La Fe University Hospital, Valencia, Spain.
出版信息
Br J Ophthalmol. 1995 May;79(5):439-41. doi: 10.1136/bjo.79.5.439.
Abstract
AIMS
A prospective, randomised, double blind, placebo controlled study of intraoperative mitomycin C as adjunctive treatment of primary pterygium was conducted.
METHODS
A total of 66 eyes of 54 patients with primary pterygium were treated with excision, with or without a single intraoperative application of mitomycin C (0.1 mg/ml for 5 minutes) to evaluate the efficacy and toxicity of this adjunctive treatment. The mean follow up was 14.1 months (range 12-23 months).
RESULTS
Of the 36 eyes that underwent simple excision, 14 (38.8%) exhibited recurrences whereas only one of 30 eyes (3.33%) treated with excision and intraoperative application of mitomycin C had recurrence (p = 0.0006). Neither serious ocular complications nor systemic toxicity were noted in the mitomycin C treated group.
CONCLUSION
Intraoperative mitomycin C appears to be an effective and safe adjunctive treatment of primary pterygium.
摘要
目的
开展一项关于术中使用丝裂霉素C作为原发性翼状胬肉辅助治疗的前瞻性、随机、双盲、安慰剂对照研究。
方法
对54例原发性翼状胬肉患者的66只眼进行手术切除，部分患者术中单次应用丝裂霉素C（0.1mg/ml，持续5分钟），以评估这种辅助治疗的疗效和毒性。平均随访时间为14.1个月（范围12 - 23个月）。
结果
单纯手术切除的36只眼中，14只（38.8%）复发，而手术切除联合术中应用丝裂霉素C治疗的30只眼中仅有1只（3.33%）复发（p = 0.0006）。丝裂霉素C治疗组未观察到严重眼部并发症和全身毒性。
结论
术中使用丝裂霉素C似乎是原发性翼状胬肉一种有效且安全的辅助治疗方法。
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