丝裂霉素C在翼状胬肉手术中的作用。
Role of mitomycin C in pterygium surgery.
作者信息
Mahar P S, Nwokora G E
机构信息
Armed Forces Hospital, Tabuk, Saudi Arabia.
出版信息
Br J Ophthalmol. 1993 Jul;77(7):433-5. doi: 10.1136/bjo.77.7.433.
Abstract
Mitomycin C in the form of eye drops in a concentration of 0.4 mg/ml (0.04%) was used as adjunctive treatment for primary and recurrent pterygium after surgical excision. The study was concurrent in nature and consisted of 32 pterygia in 30 patients and was done over a period of 36 months. The object was to observe the effect of mitomycin C drops on pterygium recurrence after surgical excision. Fifteen eyes of 15 patients were treated with 'bare sclera technique' for pterygium excision. Nine patients showed recurrence occurring within first 6 months of surgery. On the other hand 17 eyes of 15 patients after bare sclera pterygium excision received mitomycin 0.4 mg/ml (0.04%) eye drops four times a day for 2 weeks from first postoperative day. There was no recurrence of pterygium in this group. Follow up time for these cases ranged from 13-19 months.
摘要
浓度为0.4毫克/毫升（0.04%）的丝裂霉素C眼药水被用作原发性和复发性翼状胬肉手术切除后的辅助治疗。该研究为同期性研究，纳入了30例患者的32只翼状胬肉，研究历时36个月。目的是观察丝裂霉素C眼药水对手术切除后翼状胬肉复发的影响。15例患者的15只眼睛采用“单纯巩膜技术”进行翼状胬肉切除。9例患者在术后头6个月内出现复发。另一方面，15例患者的17只眼睛在单纯巩膜翼状胬肉切除术后，从术后第一天开始每天使用4次浓度为0.4毫克/毫升（0.04%）的丝裂霉素眼药水，持续2周。该组无翼状胬肉复发。这些病例的随访时间为13 - 19个月。
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本文引用的文献
1
THE SURGICAL TREATMENT OF PTERYGIUM.翼状胬肉的外科治疗
Br J Ophthalmol. 1948 Feb;32(2):65-71. doi: 10.1136/bjo.32.2.65.
2
Incidence of pterygium recurrence in patients treated with thio-tepa.
Am J Ophthalmol. 1966 May;61(5 Pt 1):891-2.
3
Inhibition of corneal vascularization by triethylene thiophosphoramide (Thio-Tepa).
Arch Ophthalmol. 1963 Mar;69:330-4. doi: 10.1001/archopht.1963.00960040336015.
4
Triethylene thiophosphoramide in the prevention of pterygium recurrence.三乙烯硫代磷酰胺预防翼状胬肉复发
Am J Ophthalmol. 1962 Nov;54:751-3.
5
The use of postoperative beta radiation in the treatment of pterygia.术后β射线在翼状胬肉治疗中的应用。
Ophthalmic Surg. 1982 Dec;13(12):1022-5.
6
Pterygium excision with or without postoperative irradiation, a double-blind study.翼状胬肉切除联合或不联合术后放疗的双盲研究。
Doc Ophthalmol. 1982 Jan 29;52(3-4):309-15. doi: 10.1007/BF01675860.
7
Postoperative beta radiation treatment of pterygium.翼状胬肉术后β射线放射治疗
Int J Radiat Oncol Biol Phys. 1983 May;9(5):679-84. doi: 10.1016/0360-3016(83)90234-1.
8
Conjunctival autograft transplantation for advanced and recurrent pterygium.结膜自体移植治疗晚期复发性翼状胬肉。
Ophthalmology. 1985 Nov;92(11):1461-70. doi: 10.1016/s0161-6420(85)33831-9.
9
Mitomycin eye drops as treatment for pterygium.
Ophthalmology. 1988 Jun;95(6):813-21. doi: 10.1016/s0161-6420(88)33104-0.
10
Postoperative instillation of low-dose mitomycin C in the treatment of primary pterygium.低剂量丝裂霉素C术后滴眼治疗原发性翼状胬肉
Am J Ophthalmol. 1988 Dec 15;106(6):715-8. doi: 10.1016/0002-9394(88)90706-4.
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