Tsagareli M G
Pathophysiology Laboratory, Serbsky Research Institute of General and Forensic Psychiatry, Moscow, Russia.
Neuroreport. 1995 Apr 19;6(6):925-8. doi: 10.1097/00001756-199504190-00025.
To investigate the number of correct responses (NCR), the reaction time (RT) and the event-related potentials (ERPs), the visuo-spatial perception of geometric figures in conditions of backward masking was studied in healthy subjects and patients with chronic alcoholism. The performance of a visuo-spatial task of mentally constructing geometric figures was found to be achieved better if a figure-standard could be formed from the presented fragments. The NCR was significantly lower and the RT longer in patients than in healthy subjects. During the solution of this task in controls the RT was shorter if the stimuli were presented in the left visual field. No interhemispheric differences were observed in alcoholics. The late components of ERPs N200 and P300 occurred with a longer latency and lesser amplitudes in patients than in normal controls. Smaller ERP amplitudes were observed in the right hemisphere. The findings support the view that in chronic alcoholism the hemispheric interaction is disturbed due to predominant deficiency of the visuo-spatial function in the right hemisphere.
为了研究正确反应数量（NCR）、反应时间（RT）和事件相关电位（ERP），我们对健康受试者和慢性酒精中毒患者在逆向掩蔽条件下对几何图形的视觉空间感知进行了研究。结果发现，如果能够根据呈现的片段形成图形标准，那么在脑海中构建几何图形的视觉空间任务的表现会更好。与健康受试者相比，患者的NCR显著更低，RT更长。在对照组完成这项任务的过程中，如果刺激出现在左视野，RT会更短。在酗酒者中未观察到半球间差异。与正常对照组相比，患者ERP的晚期成分N200和P300出现的潜伏期更长，波幅更小。在右半球观察到较小的ERP波幅。这些发现支持了这样一种观点，即在慢性酒精中毒中，由于右半球视觉空间功能的主要缺陷，半球间的相互作用受到了干扰。
