Shaw A S, Gauen L K, Zhu Y
Center for Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Semin Immunol. 1995 Feb;7(1):13-20. doi: 10.1016/1044-5323(95)90003-9.
The tyrosine activating motif (TAM) is a conserved signaling motif present in many hematopoietic receptors. Although the exact definition and the function of these motifs is not known, it is likely that these motifs bind and activate protein tyrosine kinases. Here we summarize the data regarding tyrosine kinase interactions with the T cell receptor TAMs and integrate much of the information into a functional and testable model. We propose that phosphorylated TAMs are important for the activation of tyrosine kinases as well as for the recruitment of critical signaling molecules.
酪氨酸激活基序（TAM）是存在于许多造血受体中的保守信号基序。尽管这些基序的确切定义和功能尚不清楚，但这些基序可能结合并激活蛋白酪氨酸激酶。在这里，我们总结了关于酪氨酸激酶与T细胞受体TAM相互作用的数据，并将许多信息整合到一个功能性且可测试的模型中。我们提出，磷酸化的TAM对于酪氨酸激酶的激活以及关键信号分子的募集很重要。
