Seed B
Massachusetts General Hospital, Boston 02114, USA.
Semin Immunol. 1995 Feb;7(1):3-11. doi: 10.1016/1044-5323(95)90002-0.
Receptors which induce immune system effector function bear similar intracellular sequences and respond to aggregation through a nonreceptor tyrosine kinase-dependent pathway. The mechanism by which receptor aggregation leads to cell activation is poorly understood, but recent experiments with chimeric receptors and kinases have begun to simplify the analysis.
诱导免疫系统效应器功能的受体具有相似的细胞内序列，并通过非受体酪氨酸激酶依赖性途径对聚集作出反应。受体聚集导致细胞激活的机制尚不清楚，但最近使用嵌合受体和激酶进行的实验已开始简化分析。
