Seroz T, Hwang J R, Moncollin V, Egly J M
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France.
Curr Opin Genet Dev. 1995 Apr;5(2):217-21. doi: 10.1016/0959-437x(95)80011-5.
TFIIH is a basal transcription factor for protein-coding genes. It contains ERCC2, ERCC3, MO15 and cyclin H, polypeptides implicated in nucleotide excision repair or cell cycle regulation. The dysfunction of TFIIH could result in a large panel of genetic disorders, such as xeroderma pigmentosum, Cockayne's syndrome and trichothiodystrophy. This link between transcription, DNA repair and cell cycle has highlighted a complex and essential role for TFIIH in the cell and has provided much information on the molecular mechanisms of each of these cellular processes.
TFIIH是蛋白质编码基因的基础转录因子。它包含ERCC2、ERCC3、MO15和细胞周期蛋白H，这些多肽与核苷酸切除修复或细胞周期调控有关。TFIIH功能障碍可能导致一系列遗传疾病，如着色性干皮病、科凯恩综合征和毛发硫营养不良。转录、DNA修复和细胞周期之间的这种联系突出了TFIIH在细胞中的复杂而重要的作用，并为这些细胞过程中每一个的分子机制提供了大量信息。
