核苷酸切除修复及其与转录的联系。
Nucleotide excision repair and the link with transcription.
作者信息
Lehmann A R
机构信息
MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, UK.
出版信息
Trends Biochem Sci. 1995 Oct;20(10):402-5. doi: 10.1016/s0968-0004(00)89088-x.
PMID:8533152
Abstract
Nucleotide excision repair (NER) uses the products of about 30 genes to remove a damage-containing oligonucleotide from cellular DNA. The transcription factor TFIIH is an essential component of NER. In man, defects in NER can result in three distinct genetic disorders, whose features can be ascribed to abnormalities in DNA repair or transcription.
摘要
核苷酸切除修复（NER）利用约30个基因的产物从细胞DNA中去除含有损伤的寡核苷酸。转录因子TFIIH是NER的重要组成部分。在人类中，NER缺陷可导致三种不同的遗传疾病，其特征可归因于DNA修复或转录异常。
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