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Airways remodelling in asthma: no doubt, no more?

作者信息

Bousquet J, Vignola A M, Chanez P, Campbell A M, Bonsignore G, Michel F B

机构信息

Clinique des Maladies Respiratoires, CHU Montpellier, France.

出版信息

Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):211-4. doi: 10.1159/000236980.

DOI:10.1159/000236980
PMID:7613133
Abstract

Asthma is a chronic inflammatory disease of the airways invariably associated with healing. Remodelling of the airways can be demonstrated by the activation of airways macrophages, the release of growth factors and fibrogenic cytokines, the activation of fibroblasts and myofibroblast, elastolysis and elastosynthesis, collagen deposition, increased synthesis and release of extracellular matrix components, and an increased mass of smooth muscle and mucous glands. However, the control of remodelling is still poorly understood.

摘要

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